The Effect of Dexmedetomidine as an Adjuvant to Desflurane Anesthesia on Hepatocellular Functions in Patients with Chronic Liver Disease Undergoing Lower Abdominal Surgery

The Effect of Dexmedetomidine as an Adjuvant to Desflurane Anesthesia on Hepatocellular Functions in Patients with Chronic Liver Disease Undergoing Lower Abdominal Surgery: A Randomized Controlled Study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202402578309242

Enrollment

Registered

2024-02-20

Start date

2020-12-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Dexmedetomidine

Placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Male and female Aged 30-60 years BMI between 18 and 35 Kg/m2 Child-Pugh-Turcotte class A ASA physical status classes II or III Scheduled for elective lower abdominal surgery

Exclusion criteria

Exclusion criteria: Spontaneous bacterial peritonitis Complicated cholecystitis Disseminated malignant tumor Cardiovascular disease Renal failure requiring dialysis Child-Pugh-Turcotte class B or more INR > 1.5 Platelets count = 50,000/mm3 Tense or refractory ascites Serum sodium = 120 mEq/l Allergy for the study’s medications Neurological or mental disease Bronchial asthma Hematological disorder (not caused by chronic liver disease) Pregnancy

Design outcomes

Primary

Measure	Time frame
Gamma-glutamyl transpeptidase level	—

Secondary

Measure	Time frame
Liver function tests including AST, ALT, LDH, serum albumin, serum bilirubin (total & direct).;Hemodynamic parameters including heart rate, systolic, diastolic and mean arterial pressure.;Ramsay Sedation Score ;Patient satisfaction score	—

Countries

Egypt

Contacts

Public ContactAmr Abd El Monaem

Department of Anesthesia Surgical ICU and Pain Management Faculty of Medicine Cairo University

abdelmonaem.a@email.com0000000000000

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026