Pregnancy and Childbirth
Conditions
Interventions
Postpartum magnesium sulphate therapy
24 hour group
Sponsors
University of Ilorin Teaching Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Pregnant women at gestational age = 28 weeks with live intrauterine fetus(es) scheduled for delivery or in labour. 2. Clinical diagnosis of preeclampsia with severe features using the American College of Obstetrics and Gynaecology (ACOG) as stated in the introduction.
Exclusion criteria
Exclusion criteria: 1. Comorbid maternal diagnosis of renal disease and/or seizure disorder. 2. Contraindication to MgSO4 (drug hypersensitivity, myasthenia gravis, anuria or oliguria i.e., urine output less than 25ml/hour). 3. Prior administration of any other anticonvulsants (e.g., Diazepam, phenytoin) within 24 hours before recruitment. 4. Prior administration of MgSO4 within 72 hours which is not a component of the study regimens.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of eclampsia during or after completion of the assigned magnesium sulphate regimen. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Serial maternal serum magnesium level (Samples for serum magnesium levels will be taken from the participants before the commencement of magnesium sulphate therapy, at the occurrence of convulsion, if any and at 48 hours postpartum.) • Time of ambulation after delivery • Clinical evidence of toxicity (absent tendon reflexes, respiratory rate <12 cycle per minute, cardiac arrest). | — |
Countries
Nigeria
Contacts
Public ContactSikiru Biliaminu
Consultant chemical pathologist
Outcome results
None listed