Bio-efficacy of Pro-Vitamin A-rich banana to improve vitamin A status among children in Uganda living in an area with a high burden of inflammation.

Bio-efficacy of provitamin A-rich banana to improve vitamin A status among children in Uganda living in an area with a high burden of inflammation.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202312570462474

Enrollment

210

Registered

2023-12-05

Start date

2023-10-06

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional, Metabolic, Endocrine

Interventions

Group receiving vitamin A rich banana as midmorning snack

Group of children 6 to14years receiving panfried banana poor in vitamin A

Effect of inflammation on vitamin A absorption and Total Body Stores in children 6 to 14year

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: For the Vitamin A banana bioefficacy trial: ? 6-14yrs of age ? No underlying medical conditions ? Not pregnant ? Not having received vitamin A supplementation within the last 6 months prior to the study For the Effect of Inflammation on vitamin A absorption of total body stores: ? 6-14yrs of age ? Not having received vitamin A supplementation within the last 6 months prior to the study ? No underlying medical conditions ? Not pregnant ? Inflamed (C-reactive protein = 5 mg/L, n=55 children or With Malaria) ? Or not-inflamed (C-reactive protein < 5 mg/L, n=55 children or negative for Malaria and any other common form of inflammation)

Exclusion criteria

Exclusion criteria: For the Vitamin A rich banana bioefficacy trial: ? Fever (body temperature >37.5 °C) ? C-reactive protein > 5 mg/L ? Diarrhoea within past one week ? Severe anaemia (Hb < 70 g/dl) ? Symptoms of night blindness ? Clinical symptoms of xerophthalmia ? Chronic disease ? Not able to comply with study procedures during the run-in phase (missing 3 or more feeding sessions, or not able to consume 80% or more of the age-specific amount of banana) For the Effect on Inflammation on vitamin A absorption and total body stores: ? Diarrhoea within past one week ? Severe anaemia (Hb < 70 g/dl) ? Severe Malaria ? Chronic disease ? Any portion of the stomach or the intestine removed (aside from the appendix)

Design outcomes

Primary

Measure	Time frame
The Difference in levels of Vitamin A body stores between children consuming vitamin A rich banana and children consuming banana poor in vitamin A	—

Secondary

Measure	Time frame
Difference in serum retinal and beta carotene levels between the treatment groups;Effect of inflammation on vitamin A absorption;Difference in vitamin A body stores when assessed in serum or dried blood spots	—

Countries

Uganda

Contacts

Public ContactEsther Kariuki

Senior Legal Counsel Bioversity International

esther.kariuki@cgiar.org+254729480406

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026