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Efficacy of Sodium bicarbonate buffered lidocaine anaesthetic solution

Efficacy of sodium bicarbonate buffered lidocaine hydrochloride for local anaesthesia in intra-alveolar extraction of mandibular molars: a randomised controlled double-blind study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202311916835461
Enrollment
220
Registered
2023-11-08
Start date
2021-02-02
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health Anaesthesia

Interventions

Sodium bicarbonate
Sterile water

Sponsors

myself
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients requiring intra-alveolar extraction of mandibular first and/or second molar. 2. Patients between the ages of 18-60years 3. Patients with American Society of Anesthesiologists (ASA) I and II health status at the time of treatment.

Exclusion criteria

Exclusion criteria: 1. Patients with known underlying systemic diseases such as bleeding dyscrasia and immunosuppression [e.g. uncontrolled diabetes mellitus, clotting disorder, hyperthyroidism, arteriosclerosis, cardiac insufficiency, other cardiovascular disorders, Auto-immunodeficiency Syndrome (AIDS)]. 2. Patients with allergy or hypersensitivity to any of the constituents of the anaesthetic solution in the surgical protocol. 3. Patients on anticoagulants 4. Patients taking any medications that would alter pain perception (opioids, synthetic cannabinoids, hallucinogens, antidepressants, anticonvulsants, methamphetamine, cocaine, benzodiazepines, 3,4-Methylenedioxymethamphetamine, Serotonin-Norepinephrine Re-uptake Inhibitors) 5. Patients who are current smokers and chronic alcoholics for more than two months 6. Patients with cognitive or physical impairment 7. Pregnant women and/or breastfeeding mothers 8. Inability to give informed consent 9. Teeth with abscess at the time of extraction

Design outcomes

Primary

MeasureTime frame
Efficacy in term of failure to achieve anaesthesia

Secondary

MeasureTime frame
degree of pain on injection;Anaesthetic onset of action;Comfort of the extraction procedure

Countries

Nigeria

Contacts

Public ContactEbenezer Ajoloko

Resident doctor of Department of Oral and Maxillofacial surgery at LUTH lagos

hebhinizha@gmail.com+2348166055330

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026