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The preoperative oral caffeine for the prophylaxis against spinal anesthesia induced hypotension in patients undergoing orthopedic lower limb surgery: A randomized controlled study

The preoperative oral caffeine for the prophylaxis against spinal anesthesia induced hypotension in patients undergoing orthopedic lower limb surgery: A randomized controlled study

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
PACTR
Registry ID
PACTR202311786558285
Enrollment
120
Registered
2023-11-14
Start date
2023-12-10
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System Orthopaedics Anaesthesia

Interventions

Placebo will be received

Sponsors

Mansoura university hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1- Patients of both sexes aged 18 to 70 undergoing lower limb orthopedic surgery using spinal anesthesia. 2- Height from 160 cm to 180 cm. 3- American Society of Anesthesiologist physical status I, II or III.

Exclusion criteria

Exclusion criteria: 1. Patients who refuse to participate in the study 2. Elevated BP (>160/100 mm Hg) 3. Failed spinal anesthesia 4. Patients with known cardiovascular disease 5. Patients with known cerebrovascular disease 6. Patients with known neurological, neurodegenerative or psychiatric disease 7. Patients with known liver failure 8. Clinical history of diabetes 9. Contraindication to spinal anaesthesia e.g. coagulopathy, H 10. Patients with known caffeine or coffee allergy

Design outcomes

Primary

MeasureTime frame
to investigate the efficacy of prophylactic preoperative caffeine in preventing spinal anesthesia-induced hypotension

Secondary

MeasureTime frame
the total amounts of rescue ephedrine and atropine and the incidences of nausea/vomiting requiring treatment between the groups. The incidence of post dural puncture headache and postoperative delirium will be recorded.

Countries

Egypt

Contacts

Public ContactSohila Samir

Resident of anesthesia Mansoura University Hospital

Sohilaantar@gmail.com+201012282007

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026