Vestibular training on cognitive functions in multiple sclerosis patients.

Effect of vestibular training on cognitive functions and central fatigue in multiple sclerosis patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202311670782148

Enrollment

Registered

2023-11-21

Start date

2023-02-05

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases

Interventions

Designed vestibular rehabilitation therapy in addition to aerobic endurance exercises.

Aerobic exercises in form of endurance exercise by a stationary bicycling

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? Remitting relapsing multiple sclerosis (RRMS) patients who have no relapses over the past three months. ? Duration of illness had started not more than ten years. ? Age ranged from 20 to 45 years old. ? Body mass index (BMI) ranged from 18.5 to 24.9 kg/m2. ? Mini Mental State Examination (MMSE) score = 26. ? All the patients were ambulant with mild to moderate disability according to expanded disability status scale (EDSS) = 5. ? Primary fatigued MS patients complained from fatigue for more than two months with total score of Fatigue severity scale (FSS) = 36. ? All the patients educated with at least primary level of education.

Exclusion criteria

Exclusion criteria: ? Hamilton depression rating scale score (HDRS 17) = 7. ? Sleep disturbances with Epworth sleepiness scale (ESS) = 12. ? Severe visual or auditory impairment. ? Diseases that may affect cognitive functions such as hypertension, diabetes mellitus, connective tissue disorders, thyroid disorders, renal or hepatic impairment. ? Peripheral vestibulopathy. ? Patients on medications as glucocorticoids, amantadine, betaferon, hypnotics and modafinil. ? Previous history of any orthopedic problem.

Design outcomes

Primary

Measure	Time frame
-Brain-derived neurotrophic factor (BDNF): As a family of proteins, neurotrophic factors, or “growth factors”, are directly involved in neuronal and synaptic growth. The BDNF protein is vital for cognitive performance in the short-term and for adaptations in brain morphology (e.g., plasticity) in the long-term. Indeed, the importance of BDNF for cognitive performance is a line of research that has been given a great amount of attention. Blood samples were taken from patients and controls to measure the serum level of brain-derived neurotrophic factor (BDNF).	—

Measure

Time frame

-Brain-derived neurotrophic factor (BDNF): As a family of proteins, neurotrophic factors, or “growth factors”, are directly involved in neuronal and synaptic growth. The BDNF protein is vital for cognitive performance in the short-term and for adaptations in brain morphology (e.g., plasticity) in the long-term. Indeed, the importance of BDNF for cognitive performance is a line of research that has been given a great amount of attention. Blood samples were taken from patients and controls to measure the serum level of brain-derived neurotrophic factor (BDNF).

—

Secondary

Measure	Time frame
- Pro-inflammatory cytokine tumor necrosis factor-a (TNF-a): Central fatigue is related to an increased level of pro-inflammatory cytokines, especially TNF-a.	—

Countries

Egypt

Contacts

Public ContactManar Elsayed Ismail

Associate Lecturer of Physical Therapy For Neurology Cairo University

elmanar.ismail@gmail.com+236717691

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026