comparison of adding dexmedetomidine versus fentanyl to Intrathecal local anesthetic aiming at prevention or lowering the incidence of rebound pain in patients undergoing open surgeries under spinal anesthesia. a Randomized Controlled Trial.

Dexmedetomidine Versus Fentanyl Added to Intrathecal Local Anesthetic for Prevention of Rebound Pain in Patients Undergoing Open Surgeries Under Spinal Anesthesia.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202310515862483

Enrollment

120

Registered

2023-10-18

Start date

2022-06-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery Anaesthesia

Interventions

spinal anesthesia with dexmedetomidine as adjuvant

spinal anesthesia with fentanyl as adjuvant

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing open surgeries under spinal anesthesia of both genders. American Society of Anesthesiologists physical status I and II patients.

Exclusion criteria

Exclusion criteria: Age < 18 years. Contraindications to neuraxial anesthesia (Coagulopathy, increased intracranial pressure, or local skin infection). Hypersensitivity to any of the administered drugs.

Design outcomes

Primary

Measure	Time frame
Incidence of rebound pain after wearing off of the spinal anesthesia.	—

Secondary

Measure	Time frame
Incidence of intraoperative hypotension and bradycardia. Severity of rebound pain score (RPS) Duration of the sensory block. Duration of the motor block. The deepest level of sedation at 2, 4, 6, 12, 24 hours (h) postoperatively. Patient satisfaction from pain control. Time to first intravenous (IV) meperidine requirement. Cumulative consumption of IV meperidine at 2, 4, 6, 12, 24 hours (h) postoperatively. Incidence of side effects (nausea and vomiting and pruritus).	—

Measure

Time frame

Incidence of intraoperative hypotension and bradycardia. Severity of rebound pain score (RPS) Duration of the sensory block. Duration of the motor block. The deepest level of sedation at 2, 4, 6, 12, 24 hours (h) postoperatively. Patient satisfaction from pain control. Time to first intravenous (IV) meperidine requirement. Cumulative consumption of IV meperidine at 2, 4, 6, 12, 24 hours (h) postoperatively. Incidence of side effects (nausea and vomiting and pruritus).

—

Countries

Egypt

Contacts

Public ContactNabil Abdelraouf

Professor of Anesthesia faculty of Medicine mansoura university hospitals

nabilabdelraouf60@mans.edu.eg+201142507020

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026