Malaria
Conditions
Interventions
no intervention
Sponsors
University of Gondar
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Age 6 months–70 years • No history of malaria treatment within the last 28 days • Permanent resident within 5 km radius from the HC • Plasmodium falciparum infection confirmed by microscopy • Parasitaemia level of 1,000/µl-100,000/µl asexual forms • Presence of axillary temperature = 37.5 °C or history of fever during the past 24hs • Ability to swallow oral medication • Ability to comply to the study protocol
Exclusion criteria
Exclusion criteria: • Presence of complication or danger signs of severe malaria • Presence of severe malnutrition (body mass index (BMI) <18.5 kg/m2 or z-score <3) • Presence of known diseases other than malaria (typhoid fever, typhus, hepatitis, HIV/AIDS, pneumonia and tuberculosis) • Regular medications that may interfere with AL pharmacokinetics (antiretroviral, ketoconazole and rifampicin) • History of hypersensitivity reactions to AL • Pregnancy or lactating women • Vomited twice during drug administration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| adequate clinical and parasitological response | — |
Secondary
| Measure | Time frame |
|---|---|
| Asexual parasitaemia and fever clearance | — |
Countries
Ethiopia
Contacts
Public ContactAlemayehu Nigussie
Researcher
Outcome results
None listed