Cancer Anaesthesia
Conditions
Interventions
erector spinae plane block
serratus anterior plane block
intravenous morphine when pain score by NRS exceeds 3
Sponsors
helwan university
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Female patients Type of surgery; Modified Radical Mastectomy MRM Physical status: ASA I and ASA II. Age = 35 and = 60 Years in order to standardize doses of anesthetics and decrease age group difference in responses. Body mass index (BMI): = 20 kg/m2 and = 35 kg/m2.
Exclusion criteria
Exclusion criteria: Patient refusal Known sensitivity or contraindication to drugs used in the study (local anesthetics, opioids). History of psychological disorders and/or chronic pain syndrome. Contraindication to regional anesthesia e.g. local sepsis, pre-existing peripheral neuropathies, coagulopathy and clinical skin infiltration by the tumor. Severe respiratory e.g. (sever obstructive pulmonary disease (forced expiratory volume /forced vital capacity FEV1/FVC <50% or sever restrictive pulmonary disease (total lung capacity TLC<40%), adult respiratory distress syndrome) or sever cardiac disorders e.g. (heart failure). (Martinez-Pitre, Sabbula and Cascella, 2021) Advanced liver disease (Elevated liver enzymes more than 3 folds of normal range). Advanced kidney disease (Decreased creatinine clearance <40 ml/min). (Stevens et al., 2006) Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to compare between the two blocks and control group regarding pain scores by numerical rating scale.;to compare between the two blocks and control group regarding stress response by serum cortisol. | — |
Secondary
| Measure | Time frame |
|---|---|
| overall fentanyl consumption during operation;total morphine consumption in first 24 hour after surgery;postoperative nausea and vomiting;postoperative respiratory depression | — |
Countries
Egypt
Contacts
Public Contactmotaaz salah
lecturer of anesthesia faculty of medicine helwan university
Outcome results
None listed