Effect of preoperative vaginal preparation with 0.3% chlorhexidine-cetrimide versus 10% povidone-iodine on post cesarean section infection in obstetric care facility in Lagos

Effect of preoperative vaginal preparation with 0.3% chlorhexidine-cetrimide versus 10% povidone-iodine on post cesarean section infection.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202308689414142

Enrollment

250

Registered

2023-08-04

Start date

2023-08-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SURGICAL SITE INFECTIONS, ENDOMETRITIS AND ENDOMYOMETRITIS

Interventions

CHLOROHEXIDINE GROUP

POVIDONE IODINE

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: - Ages eligible for study: =18 years - All pregnant women with gestational age of 28 weeks and above. - Pregnant women with indication for emergency or elective Cesarean section. - Patient must give informed consent.

Exclusion criteria

Exclusion criteria: - Allergy/Contraindications to either Povidone-Iodine (thyroid disease) and Chlorhexidine - Obstructed Labour - Active genital herpes - Face Presentation - Antepartum hemorrhage, cord prolapse with life fetus - Active Chorioamnionitis, - Women on chronic steroid use, Diabetes Mellitus, HIV infection, - Intrauterine Fetal Death - Evidence of pre-operative skin infection - Women considered for a hysterectomy at the time a decision for Cesarean section was made were also excluded.

Design outcomes

Primary

Measure	Time frame
The primary outcome to be measured is the difference between the incidence of post-caesarean section composite infectious morbidities between participants on preoperative vaginal cleansing with Chlorhexidine solution and those on preoperative vaginal cleansing with Povidone-iodine.	—

Secondary

Measure	Time frame
1. Incidence of post-operative endometritis in respective study groups. 2. Incidence of post-operative febrile morbidities in respective study groups. 3. Incidence of post-operative wound infections in respective study groups. 4. The frequency of patient-reported vaginal symptoms (dryness, burning, itchiness, unusual vaginal discharge, pain or burning with urination) with Chlorhexidine or Povidone-Iodine vaginal cleansing in respective study groups. 5. The bacteriological aetiology for SSI following caesarean section and their antimicrobial susceptibility patterns in respective study groups. 6. Neonatal 1st & 5 minutes APGAR score (fetal outcome) after treatment with Chlorhexidine or Povidone-Iodine vaginal cleansing in respective study groups	—

Measure

Time frame

1. Incidence of post-operative endometritis in respective study groups. 2. Incidence of post-operative febrile morbidities in respective study groups. 3. Incidence of post-operative wound infections in respective study groups. 4. The frequency of patient-reported vaginal symptoms (dryness, burning, itchiness, unusual vaginal discharge, pain or burning with urination) with Chlorhexidine or Povidone-Iodine vaginal cleansing in respective study groups. 5. The bacteriological aetiology for SSI following caesarean section and their antimicrobial susceptibility patterns in respective study groups. 6. Neonatal 1st & 5 minutes APGAR score (fetal outcome) after treatment with Chlorhexidine or Povidone-Iodine vaginal cleansing in respective study groups

—

Countries

Nigeria

Contacts

Public ContactOLUWAKEMI WINDAPO

COLLEAGUE

bolawindapo@gmail.com+2348023099282

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026