HIV/AIDS
Conditions
Interventions
Standard of care
Sponsors
London School of Hygiene and Tropical Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 16-24 years. 2. Taking ART for at least 6 months 3. Custodian of a mobile phone to prevent inadvertent HIV disclosure and able to receive text messages on the mobile phone 4. VL result >200 copies/ml taken within the last six months. If no recent viral load done within the last six months a viral load sample will be collected as part of screening. 5. A firm home address in Greater Harare accessible for visiting and intending to remain there for 9 months 6. Positive HIV status known by participant 7. Consenting to participate in the study and to give blood samples
Exclusion criteria
Exclusion criteria: 1. Any condition (except HIV) that may prove fatal during the study period (e.g. malignancy, end-stage HIV disease or other conditions deemed likely fatal by the principal investigator). 2. Conditions likely to lead to lack of understanding of study procedures or to uncooperative behaviour e.g. neurocognitive disease, developmental delay, psychiatric illness or any other illness that may result in failure to understand study procedures (based on clinical assessment). 3. Living in the same household as a trial participant (to avoid inadvertent mix-up of intervention components) 4. Concurrent participation in other interventional studies addressing adherence
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of participants with suppressed viral load (<50 copies/ml) | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of participants with viral load 200 copies/ml) at 9 months;Change in proportion of participants with GRT mutations;Number of antiretroviral therapy regimen switches;Mean adherence to ART as measured by the EMD - intervention participants only;Adherence behaviour patterns using machine learning techniques;Mean adherence to ART as measured by pill count, self-report and pharmacy refill | — |
Countries
Zimbabwe
Contacts
Public ContactMufaro Makuni
Communications and public engagement officer
Outcome results
None listed