Circulatory System Nutritional, Metabolic, Endocrine
Conditions
Interventions
Potassium enriched low sodium salt substitute
Usual table salt
Sponsors
MRC Wits Developmental Pathways for Health Research Unit
Wits Health Hubb
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male/Female. 2. African descent living in Soweto. 3. Adolescents, aged 13-19 years, primary caregiver (parent/guardian) and where the primary caregiver is <40 years of age, also a member of the household (aged 40-70 years). 4. Eats in the home a minimum of five days a week. 5. Stays in the home a minimum of five days a week. 6. Individuals presenting with new clinical hypertension (will be referred). 7. Use of ACE inhibitors or Angiotensin receptor blockers (participant will be flagged for monitoring.
Exclusion criteria
Exclusion criteria: 1. Inability to read or understand English. 2. Self-reported previous diagnosis of kidney disease/diminished kidney function (any household member regardless of participation). 3. Urine dipstick indicating potential kidney disease/diminished kidney function as indicated by proteinurea (any household member regardless of participation). 4. Estimated Glomerular Filtration Rate below 60 mL/min (any household member over 20 years of age regardless of participation). 5. Use of Potassium-sparing diuretics (any household member regardless of participation). 6. Potential contraindication to the potassium-enriched salt (any household member regardless of participation). 7. Considered to eat most meals outside of the home. 8. Previous diagnosis or currently self-reporting any eating disorder. 9. Participating in any other trial. 10. Households without cooking facilities. 11. High-level athletes. 12. Self-reported pregnancy at time of screening (any household member regardless of participation).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In adolescents and adults: Difference in change in spot urinary sodium-to-potassium molar ratio from baseline to 16 weeks.;In adults: Difference in change in systolic BP from baseline to 16 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| In adolescents: Difference in change in systolic and diastolic BP from baseline to 16 weeks.;In adults: Difference in change in diastolic BP and spot urinary sodium-to-potassium molar ratio from baseline to 16 weeks. | — |
Countries
South Africa
Contacts
Public ContactSimone Crouch
Post Doctoral Fellow
Outcome results
None listed