Respiratory Paediatrics
Conditions
Interventions
intrapleural Alteplase or Streptokinase injection in Children with Empyema or conservative approach
intrapleural streptokinase injection
Sponsors
Assiut University Children Hospital.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Age: from1 month to18 years. Gender: both sexes will be included in the study. Empyema or CPPE along with evidence of septated pleural effusion on chest ultrasonography. All patients will undergo chest tube insertion along with intravenous antibiotics.
Exclusion criteria
Exclusion criteria: Age below 1 month. Patients with chronic empyema which is characterized by thickened visceral and parietal peels which hamper the ability of affected lung to re-expand and required definitive surgical intervention. Patients with bleeding tendency, recent trauma, recent operation and on anticoagulation. Children with pleural empyema from tuberculosis or malignancy. Children with allergy to tPA or streptokinase. Children with minimal parapneumonic effusion that do not require chest tube insertion. Presence of bronchopleural fistula or pyopneumothorax.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is assessment of the benefit and possible complications of intrapleural injection of tissue plasminogen activator and streptokinase in children with CPPE or empyema. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare between intrapleural injection of tissue plasminogen activator versus streptokinase in children with CPPE or empyema in reducing the need of further surgical intervention. | — |
Countries
Egypt
Contacts
Public ContactMohamed Sayed
Lecturer
Outcome results
None listed