Digestive System Nutritional, Metabolic, Endocrine Paediatrics
Conditions
Interventions
Sponsors
Washington University in St. Louis
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: At least 6 months of age and less than 30 months of age Mid-upper arm circumference < 12. 5 cm Mid-upper arm circumference-for-age z-score < -2 Provision of signed (or thumb-printed) and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study, including no plan to move from the catchment area of a participating clinic
Exclusion criteria
Exclusion criteria: Nutritional edema Simultaneous involvement in another research trial or supplementary feeding program Chronic debilitating illness Allergy to egg Receipt of treatment for acute malnutrition within 1 month prior to screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percent lactulose (% L) excretion at 12 and 24 weeks;Change in length-for-age z-score after 12 and 24 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Host fecal mRNA transcription profile;Proportion of children with no vs. severe (%L > 0.45) EED;Proportion stunted;Percent lactulose excretion at 6 weeks;Rate of length gain;Deterioration to severe acute malnutrition or death;Rate of weight gain;Recurrence of MAM;Fecal protein markers AAT, MPO, NEO | — |
Countries
Sierra Leone
Contacts
Public ContactDonna Wegner
Senior Grant Specialist in Department of Pediatrics
Outcome results
None listed