Sulfadoxine Pyrimethamine with Azithromycin versus Sulfadoxine Pyrimethamine alone for malaria chemoprophylaxis in pregnancy

A comparison of the efficacy of sulfadoxine pyrimethamine with azithromycin versus sulfadoxine pyrimethamine alone for malaria chemoprophylaxis in pregnancy: A triple blind randomized control trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202305696485090

Enrollment

100

Registered

2023-05-12

Start date

2023-05-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth

Interventions

Sulfadoxine Pyrimethamine plus placebo

Sulfadoxine Pyrimethamine with Azithromycin

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: -Booked Ante Natal patient in Federal Medical Centre, Asaba, Delta state - Willingness to provide informed consent - Gestational age greater than or equal to 13 weeks

Exclusion criteria

Exclusion criteria: - Known drug allergy to Sulfadoxine Pyrimethamine - Known drug allergy to Azithromycin - Multiple Gestation - Clinical signs/ symptoms of Malaria - Laboratory positive blood film for Malaria parasite - Packed Cell Volume less than 30% - Sickle Cell Disease - Human Immunodeficiency Infection

Design outcomes

Primary

Measure	Time frame
1.Present of Malaria parasites in the mother, fetus and placenta at delivery	—

Secondary

Measure	Time frame
Maternal packed cell volume, and fetal birth weight	—

Countries

Nigeria

Contacts

Public ContactRobinson Ogwu

Senior Registrar

robinsonogwu@gmail.com+2348023764840

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026