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Dexmedetomidine versus Haloperidol efficacy on intra-abdominal pressure, inflammatory response and duration of mechanical ventilation in patients with abdominal sepsis: Comparative Study Controlled by Propofol

Dexmedetomidine versus Haloperidol efficacy on intra-abdominal pressure, inflammatory response and duration of mechanical ventilation in patients with abdominal sepsis: Comparative Study Controlled by Propofol

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202305682901262
Enrollment
90
Registered
2023-05-11
Start date
2023-04-05
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Propofol group
Haloperidol group
Dexmedetomidine group

Sponsors

sherif kamal hafez arafa
Lead Sponsor
sherif kamal hafez arafa
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1-adult patients = 18 years old till 70 years old 2- diagnosed with intestinal obstruction or abdominal sepsis, 3- who underwent abdominal surgery to control the source of infection and required postoperative sedation for mechanical ventilation 4- SOFA score = 2 points due to intra-abdominal infection.

Exclusion criteria

Exclusion criteria: 1- patients less than 18 years and more than 70 2- Ischemic heart diseases and heart failure 3-patient with cerebrovascular event 4- patients with neurological deficit 5-pateints with source of infection other than abdominal infection

Design outcomes

Primary

MeasureTime frame
to investigate the effects of sedation of patients with abdominal sepsis with dexmedetomidine versus sedation with propofol and effects on inflammatory mediators as IL-6, IL-8 and serum lactate level—

Secondary

MeasureTime frame
Intra-abdominal hypertension (IAH) ,icu hospital stay and mortality—

Countries

Egypt

Contacts

Public Contactsherif arafa

assisstant professor of anesthesia and surgical ICU

sherifarafa1020@gmail.com00201005714014

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026