side effects of intrathecal morphine in orthopedic surgery

The impact of adding Nalbuphine or Naloxone to intrathecal morphine as adjuvants on morphine linked side effects in orthopedic surgery: A randomized controlled study.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202303901133915

Enrollment

126

Registered

2023-03-31

Start date

2023-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery Orthopaedics Anaesthesia

Interventions

intrathecal anesthesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: both sex ASA physical status I &II age 50-80 years old scheduled to undergoing elective lower orthopedic surgery.

Exclusion criteria

Exclusion criteria: • Body mass index = 35. • Diabetes Mellitus • Allergy to the study drugs. • Chronic alcoholism. • Patient with significant neurological and psychiatric disorders. • Any contraindications to spinal anesthesia.

Design outcomes

Primary

Measure	Time frame
adverse effects nausea, pruritus,urinary retention	—

Secondary

Measure	Time frame
onset of sensory and motor block;duration of sensory block;duration of motor block;pain assessment by visual analog scale VAS score postoperative;Total amount of rescue analgesics that required postoperative;Hemodynamics changes: heart rate and mean arterial blood pressure	—

Countries

Egypt

Contacts

Public ContactMarwa Elfert

lecturer

dr.marwaoraby5@gmail.com+201008618309

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026