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Efficacy of Perioperative Infusion of N (2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: Randomized Control Trial

Efficacy of Perioperative Infusion of N (2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: Randomized Control Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
PACTR
Registry ID
PACTR202303692483097
Enrollment
90
Registered
2023-03-22
Start date
2022-07-03
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System Nutritional, Metabolic, Endocrine Surgery Cardiology Anaesthesia

Interventions

Dipeptiven group
Control group

Sponsors

cardiothoracic academy
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: • All urgent cases of coronary artery bypass surgery whether isolated or combined with mitral valve surgery. • Uncontrolled diabetes mellitus with Hb A1C >7.0 • ASA physical status 2-5 • Sex (males and females) • Age 18-70 years.

Exclusion criteria

Exclusion criteria: • Patients are refusing to participate in the study. • Below 18 or above 60 years. • Patients with preoperative abnormal hepatic profiles identified by double average values of ALT/AST or bilirubin or hypoalbuminemia • Patients with preoperative renal impairment identified by serum creatinine of more than 1.7 mg/dL • Patient with a history of malignant tumors.

Design outcomes

Primary

MeasureTime frame
Mean intraoperative glucose level.—

Secondary

MeasureTime frame
• Perioperative dynamic of troponin I ;• Total insulin infusion in first 24 hours;• Incidence of diabetic ketoacidosis—

Countries

Egypt

Contacts

Public ContactMohammed Mohsen

lecturer of anesthesia faculty of medicine Ain Shams university

mohamed_mohsen@med.asu.edu.eg+201204227780

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026