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A comparative study on the effectiveness and safety of Azadirachta indica leaf extract versus chlorhexidine mouth rinses on postoperative complications following mandibular third molar surgeries: a randomized, double-blinded controlled study.

A comparative study on the effectiveness and safety of Azadirachta indica leaf extract versus chlorhexidine mouth rinses on postoperative complications following mandibular third molar surgeries: a randomized, double-blinded controlled study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202301888753718
Enrollment
42
Registered
2023-01-17
Start date
2023-01-18
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health

Interventions

Azadirachta Indica group

Sponsors

Dr. Patience Ewere Ofiri
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age- 18-50 years. 2. Healthy patients (ASA I and II status). 3. Patients who did not use any antibiotic or anti-inflammatory agent 7 days prior to surgery. 4. Patients who understood the procedure and agreed to sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with acute local infection at the operation site 2. Patients with systemic conditions like uncontrolled diabetes, uncontrolled hypertension, and blood dyscrasias. 3. Patients who were poorly motivated. 4. Patients whose duration of surgery exceeded 45 minutes 5. Patients whose dentition lacks natural opposing central incisors or prosthetic equivalent which would not allow standardization of the measurement of the maximum inter-incisal opening. 6. Patients on medications that might influence the surgical procedure or affect wound healing e.g., anticoagulants, and corticosteroids. 7. Patients with impacted third molars along a fracture line 8. Patients who were smokers. 9. Patient who are alcoholics 10. Patients who presented with impacted mandibular third molars assessed as ‘difficult’ using the Pederson Index. 11. Patients who had a history of head and neck cancer or radiotherapy. 12. Patients who were pregnant or lactating.

Design outcomes

Primary

MeasureTime frame
Postoperative complications included the following signs and symptoms: alveolar infection; alveolar osteitis; trismus; pain (as assessed by a visual analog scale); and facial swelling as measured by the Laskin method.

Secondary

MeasureTime frame
Delayed wound healing using IPR Wound Healing Scale

Countries

Nigeria

Contacts

Public ContactLawrence O. Igbinosa

Ugbowo

surglaw@yahoo.com+2348038101970

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026