Nutritional, Metabolic, Endocrine
Conditions
Interventions
NORMAL SALINE
Sponsors
Souissi Sami
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients of both genders Aged more than 16 years old Admitted in the emergency department of moderate to severe ketoacidosis defined by: hyperglycemia > 2.5 g/L and Acetonuria > + and pH 12 mmol/l
Exclusion criteria
Exclusion criteria: - Patients with chronic renal failure (renal clearance less than 30 ml / minute - Patients with state of shock defined by: SBP < 90 mmHg with signs of peripheral hypoperfusion. - The association with severe pathology: Myocardial ischemia, Septic shock, Acute pancreatitis, Acute surgical pathology. -Patients transferred before the end of the protocol - Secondary hemodynamic instability requiring the use of vasoactive drugs - Withdrawal of consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time (h) to recover from acidosis defined by a pH > 7.35 and HCO3- > 18 mmol/l | — |
Secondary
| Measure | Time frame |
|---|---|
| Total duration of stay in ED ;Incidence of hyperchloremic acidosis defined by pH< 7.35 with delta AG/delta bicarbonates < 1 ;Incidence of cerebral edema ;developement of signs of overload ;Impairment of kidney function | — |
Countries
Tunisia
Contacts
Public ContactSarra Akkeri
Doctor
Outcome results
None listed