Nutritional, Metabolic, Endocrine
Conditions
Interventions
Training and Early Timed restricted eating
Training and late timed restricted eating
Late Timed restricted eating
Evaluation without physical training and TRE
Sponsors
Research laboratory LINP2
Biochemistry and Toxicology laboratory
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: *Overweight and obese patients under 60 years old *BMI >=25 kg /m² *Sedentary and able to practice physical exercise * Stable Weight for the last 6 months * Agree to eat meals during given times of the day
Exclusion criteria
Exclusion criteria: * 6 months before the study: Taking any type of antioxidant substances, vitamins or anti-inflammatory drugs. * No hormonal treatments or sleeping pills (hypnotics and anxiolytics) two weeks before the study * Patients who have undergone a rehabilitation protocol * Smoking, alcoholism, drugs * Other chronic or autoimmune neurodegenerative comorbidities. * Diabetes, osteoporosis, other neurological, vestibular, cognitive, orthopedic, and psychiatric disorders. *Any contraindication to the practice of a physical activity (serious cardiovascular or pulmonary diseases). * Pregnant or lactating women in the last six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1- Body composition (weight, Body Fat Mass, Lean mass, Bone Mass, Muscle mass and Body Water) will be measured throw impedancemetr . 2- Cardio-respiraotry capacity will be measured during 6 minutes walking test with using spirometry one time: pre intervention.Systolic blood pressure and diastolic blood pressure using blood pressure monitor. 3- Change in Physical parameters : static and dynamic balance measurements will be performed throw Y balance test with both legs (write and left.) Aerobic capacity and respiratory volumes will be measured using 6 minutes walking test and spirometry. Pulsed" oxygen saturation using Pulse oximeter - SpO2 saturometer. The abalakov jump test will be used to measure leg power.Maximum muscle strength will be determined using a maximum repetition test (1RM), women will attempt to familiarize themselves with each of the resistance machines (leg press) (weight bench with loaded bars) by performing 8-10 reps of a light load (~50% of expected 1RM), followed by (80 % of estimated 1RM). After each successful performance, the weight would increase until an unsuccessful attempt occurred. 4- Change in biochemical parameters: change in lipid profile(i.e. Total Cholesterol (TC), High-density lipoprotein (HDL), Lowdensity lipoprotein (LDL) and Triglycerides (TG)) will be measured enzymatically. Change in hepatic profile : dosage of transaminases, alkaline phosphatase, gamma glutamyl transpeptidase and bilirubin. Change in thyroidien profile: FT4 and TSH CRP will be measured with Latex particle immunoturbidimetric test. Change in hormones:Cortisol and Insulin concentrations Change in Glucose metabolism included fasting glycemia, and HOMA-IR levels | — |
Secondary
| Measure | Time frame |
|---|---|
| 1-Change in eating behavior parameters will be measured using differents Questionnaires ( TFEQ : Three factor eating Questionnaire, EDE-Q : Eating disorders diagnosis and EDRSQ-F : Eating disorder.) 2- change in cognitive function will be assessed using the Mini Mental State (MMSE) and Barrage numbers tests which assesses different cognitive domains: attention and concentration, executive functions, memory, language, Visuoconstructional skills, conceptual thinking, calculations and orientation, 3- Change in Psychological parameters will be measured using SEPOB questionnaire that assesses the feeling of self-efficacy specific to obesity. 4- change in sleep quality will be evaluated using Sleep Diary * Epworth sleepiness scale: include eight questions, and its total score varies between 0 and 10 and whose score equal to or more 10 corresponds to sleep disorders. * Actimetry. 5- Change in Quality of life will be evaluated by The Short Form Health Survey (SF36) which includes 36 items divided into 8 dimensions (physical activity, life and relationships with others, physical pain, perceived health, vitality, limitations due to mental state, limitations due to physical condition and mental health) 6-Physiological response: change in Cardiac variability, resting heart rate will be assessed using (Polar V 800). | — |
Countries
Tunisia
Contacts
Public Contactranya;Samar amer;Miladi
The Research Unit of ISSEPS sfax; The Research Unit of Isseps Sfax
Outcome results
None listed