Herbal preparation for the treatment of COVID-19: Randomized clinical trial to test the safety and efficacy on the viral clearance of SARS-CoV-2

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

PACTR

Registry ID

PACTR202210816121866

Enrollment

120

Registered

2022-10-27

Start date

2022-10-31

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory

Interventions

COMARUS

National treatment Group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Presence of SARS-CoV-2 Respiratory rate (RR) 10-30/min PaO2/FiO2 > 300 mmHg SatO2 >95% in AA No organ failure

Exclusion criteria

Exclusion criteria: Patients who did not have a follow-up laboratory test Patients with symptoms classified as severe to critical, Patients with hepatic, renal and/or hematological laboratory disturbances hematological disturbances. Severe case at least one of the following signs Respiratory rate (RR) > 30/min ; SatO2 <93% in AA PaO2/FiO2 < 300 mmHg No organ failure Critical at least one of the signs Respiratory distress requiring mechanical ventilation Multi-organ failure Shock

Design outcomes

Primary

Measure	Time frame
Doses will be considered non-toxic when the values obtained for the biochemical and hematological parameters are comparable before and after dosing in uninfected subjects with SARS-CoV-2 without signs of Covid-19. The intervention is effective when the time of clearance of the viral load obtained by the administration of different doses of the COMARUS Syrup is comparable with the clearance time obtained with the national treatment scheme	—

Measure

Time frame

Doses will be considered non-toxic when the values obtained for the biochemical and hematological parameters are comparable before and after dosing in uninfected subjects with SARS-CoV-2 without signs of Covid-19. The intervention is effective when the time of clearance of the viral load obtained by the administration of different doses of the COMARUS Syrup is comparable with the clearance time obtained with the national treatment scheme

—

Secondary

Measure	Time frame
The intervention is effective when patients do not develop develop severe signs of the disease and no longer carry SARS-CoV-2 by the negativation of 2 successive tests by real-time PCR in comparison with the national treatment protocol	—

Countries

Mali

Contacts

Public ContactSekou Oumar DEMBELE

Advisor in the Ministry of Health

dembele_sekou@yahoo.fr00223760209

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026