VENTILATOR INSPIRATORY TRIGGER SENSITIVITY ADJUSTMENT VERSUS THRESHOLD DEVICE TRAINING ON DIFFICULT TO WEAN GUILLAIN BARRE PATIENTS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202209768392751

Enrollment

Registered

2022-09-07

Start date

2022-08-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases Respiratory

Interventions

inspiratory muscle training

inspiratory muscle training via changes in ventilator pressure setting

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patient selection will be according to the following criteria: 1. Difficult to wean guillain barre patients who have been on MV for at least 48 hours. Difficult to wean subjects have been defined as those who fail the first spontaneous breathing trial (SBT)and may require up to 3 SBTs or up to 7 d from the first attempt to achieve successful weaning (B´eduneau G. et al.,2017) and(Annia F. et al.,2019). 2. Age: >18 years. 3. Both sexes will be included. 4. Ventilator mode: Pressure support mode with FiO2= 0.5, positive end expiratory pressure (PEEP) will be7.25, arterial oxygen saturation >90%. 8. Cardiovascular stability. 9. Maximal inspiratory pressure from 15 to 30 cm H2O and able to trigger spontaneous breaths on ventilator.

Exclusion criteria

Exclusion criteria: The participants will be excluded if they meet one of the following criteria: 1. Persistent hemodynamic instability as life threatening arrhythmias, acute heart failure. 2. Severe breathlessness, when spontaneously breathing. 3. Any progressive neuromuscular disease that would interfere with responding to inspiratory muscle training(non-stationary course). 4. Spinal cord injury. 5. Skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs. 6. Patients on heavy sedation and respiratory muscle paralysis. 7. High peak airway pressure (barotraumas). 8. BMI = 40.

Design outcomes

Primary

Measure	Time frame
time for complete weaning and ventilator free days	—

Secondary

Measure	Time frame
a) Spontaneous breathing trial;b) Blood Gas analysis;c) Mechanical ventilator variables and lung mechanics measurements according to Ghiani et al., 2020;d) Glascow coma scale ;e) Riker Sedation-Agitation Scale	—

Countries

Egypt

Contacts

Public ContactDONIA MOHAMED ELMASRY

Lecturer

sweetgirl_some@hotmail.com00201005587119

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026