Effect of N-Acetylcysteine on moderate to severe traumatic brain injury patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202209548995270

Enrollment

Registered

2022-09-22

Start date

2022-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injury, Occupational Diseases, Poisoning Nervous System Diseases

Interventions

No Drug

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Males or Females from 18 to 90 Years. 2. Hospital admission in the first 24 h of injury. 3. Moderate to severe traumatic brain injury (GCS score = 12) 4. The ability to tolerate enteral feeding. 5. Consenting guardian / relative.

Exclusion criteria

Exclusion criteria: 1. Pregnant and breast-feeding women 2. Late presentation to hospital >24 hours. 3. Pre-existing hepatic failure. 4. Pre-existing renal failure.

Design outcomes

Primary

Measure	Time frame
•Difference between the two groups in NSE levels on day 7	—

Secondary

Measure	Time frame
• Difference between the two groups in S100B levels on day 7 • Difference between the two groups in MDA levels on day 7 • Difference between the two groups in IL-6 levels on day 7 • Glasgow coma scale (GCS)	—

Countries

Egypt

Contacts

Public ContactAlaa Gouda

Department of Clinical Pharmacy Faculty of pharmacy Damanhour University.

gs-alaa.gouda@alexu.edu.eg+201069235436

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026