Therapeutic effect of early cardiac rehabilitation combined with melatonin supplementation after acute myocardial infarction treated by primary percutaneous coronary intervention.

Chronic effect of early cardiac rehabilitation combined with melatonin supplementation on myocardial function, aerobic capacity, endothelial function, oxidative stress, autonomic cardiac function and sleep quality in patients with acute myocardial infarction treated by primary percutaneous coronary intervention.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202208834230748

Enrollment

Registered

2022-08-15

Start date

2022-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiology

Interventions

Evaluation without cardiac rehabilitation and melatonin suppelmentation

Cardiac rehabilitation combined with melatonin supplementation

Cardiac rehabilitation combined with placebo supplementation

melatoning supplementation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A recent MI treated by primary percutaneous coronary intervention

Exclusion criteria

Exclusion criteria: Chronic heart failure with left ventricular ejection fraction < 45% before the acute MI Recent valve surgery Musculoskeletal limitation Uncontrolled arrhythmia, hypertension, diabetes, or additional issues that would preclude potential participation in the program

Design outcomes

Primary

Measure	Time frame
Aerobic capacity measured by VO2 peak and 6 minute walk test , sleep quality evaluated by Spiegel questionnaire and actigraphy,myocardial function evaluated by Left Ventricule Ejection Fraction,autonomic cardiac function evaluated by heart rate variability, total antioxidant capacity	—

Secondary

Measure	Time frame
Level of physical activity evaluated by International Physical Activity Questionnaire and Ricci Gagnon, Body Mass Index , Maximal Heart Rate , Systolic and diastolic blood pressure, Quality of life evaluated by Minnestosa Living With Heart Failure Questionnaire	—

Countries

Tunisia

Contacts

Public ContactMohamed Ali Hbaieb

PhD Student at University of Poitiers MOVE laboratory UR 20296

mohamed.ali.hbaieb@univ-poitiers.fr+21694660000

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026