Cancer
Conditions
Interventions
Alpha lipoic a group
placebo group
Sponsors
aculty of medicine of tanta university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Children of newly diagnosed acute lymphoblastic leukemia
Exclusion criteria
Exclusion criteria: patients with history of liver disease or active hepatitis (serum transaminases more than three times the upper limit of normal), potential exposure to agents capable of damaging the liver (such as heavy metals or solvents), regular consumption of drugs other than MTX with potential hepatotoxicity, renal impairment (serum creatinine more than twice the upper limit of normal), sepsis or active infection, relapse or secondary malignancy, serious complications that may necessitate cessation of chemotherapy for undetermined duration will be excluded in our study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the liver function tests including ALT, AST, alkaline phosphatase (ALP), and g-glutamyl transpeptidase (GGP). | — |
Secondary
| Measure | Time frame |
|---|---|
| levels of oxidative stress such as malondialdhyde, glutathione, and superoxide dismutase | — |
Countries
Egypt
Contacts
Public ContactMohamed Elkashlan
consultant of anesthesiology
Outcome results
None listed