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Comparative study of labor induction by Misoprostol on maternal and perinatal prognosis

Efficacy and Safety of Labor Induction by Oral versus Vaginal Misoprostol: A Randomized Controlled Clinical Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202208496861650
Enrollment
177
Registered
2022-08-11
Start date
2022-09-01
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth

Interventions

Vaginal Misoprostol

Sponsors

Matega Habiragi
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Nulliparous and multiparous, followed prenatal counselling in one of the selected structures, term pregnancy, one fetus, fetal heart sounds within the norms (110-160 beats per minute) and cephalic presentation

Exclusion criteria

Exclusion criteria: Women who have already given birth more than 5 times, pregnant women with twin or multiple pregnancies, gravid hypertension, preeclampsia, gestational diabetes or chronic unbalanced diabetes, uterine height greater than 36 cm presentation other than cephalic, fetal heart rhythm disorders before induction, placenta previa, pregnancy on fibromyomatous uterus, petal-pelvic disproportion, pelvic anomalies, fetal death.

Design outcomes

Primary

MeasureTime frame
The primary outcomes were the effectiveness of Misoprostol in inducing uterine contractions by both routes

Secondary

MeasureTime frame
Secondary outcomes were the safety of the route of administration as well as its assessment elements which were time to first uterine contractions compared to the first dose, duration of labor and rate of vaginal delivery, the maternal prognosis: hyperkinesia, hypertonia, prerupture or uterine rupture, cesarean section rate, postpartum hemorrhage, fever, chills, nausea, vomiting, diarrhea, and perinatal prognosis: fetal distress, meconium staining of amniotic fluid, Apgar score at the first, fifth and tenth minute, need and duration of resuscitation, perinatal mortality.

Countries

Zaire

Contacts

Public ContactMaindo Alongo

Gynecologist and Obstetrician Kisangani University

maindo21@gmail.com+243851970360

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026