Impact of prophylactic continuous positive airway pressure in the delivery room (DR-CPAP) on neonates <1500g in a low-resource setting: A feasibility trial

Conditions

Paediatrics

Nakiyemba A, Napyo A, Muduwa M, Ssenkusu JM, Okello F, Hagmann C, Namuyonga J, Hewitt-Smith A, Loe K, Abongo G, Amorut D, Wandabwa J, Olupot-Olupot P, Burgoine K.

2026-06-05

10.1186/s12910-026-01514-3

Acceptability of immediate CPAP for preterm infants in the delivery room to mothers, caregivers and healthcare workers in a low-resource setting: a qualitative study

Agnes, Napyo, Nakiyemba, Alice, Muduwa, Martha, Ssenkusu, John M., Okello, Francis et al. (14 authors)

Universität Zürich, ZORA2025-09-24

10.5167/uzh-279799

Acceptability of immediate CPAP for preterm infants in the delivery room to mothers, caregivers and healthcare workers in a low-resource setting: a qualitative study.

Napyo A, Nakiyemba A, Muduwa M, Ssenkusu JM, Okello F, Hagmann C, Namuyonga J, Hewitt-Smith A, Loe K, Grace A, Denis A, Wandabwa J, Olupot-Olupot P, Burgoine K.

2025-09-24

10.1186/s12887-025-06055-z

Impact of early continuous positive airway pressure in the delivery room (DR-CPAP) on neonates < 1500 g in a low-resource setting: a protocol for a pilot feasibility and acceptability randomized controlled trial.

Burgoine K, Ssenkusu JM, Nakiyemba A, Okello F, Napyo A, Hagmann C, Namuyonga J, Hewitt-Smith A, Martha M, Loe K, Grace A, Denis A, Wandabwa J, Olupot-Olupot P.

2024-10-041 citations

10.1186/s40814-024-01552-x

Interventions

Delivery Room Continuous Positive Airways Pressure DRCPAP

standard bCPAP SbCPAP

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Liveborn infants born weighing <1500g • Infants born in Mbale RRH • Mother who can understand English, Luganda, Ateso or Lumasaba • Mother is willing and able to give informed, written consent for participation of her infant in the study. • Mother aged 18 years or above, or those under 18 so long as emancipated.

Exclusion criteria

Exclusion criteria: • Infants born weighing =1500g • Stillborn infants • Infants born outside of Mbale RRH • Mother who can not understand English, Luganda, Ateso or Lumasaba • Maternal death • Infants with major congenital abnormality e.g. gastroschisis, cyanotic heart disease

Design outcomes

Primary

Measure	Time frame
Neonatal mortality - death before 28 days of age	—

Secondary

Measure	Time frame
• Total time on CPAP (days) • High grade (grades III and IV) intraventricular haemorrhage on cranial ultrasound before 7 days of age • Haemodynamically significant patent ductus arteriosus on echocardiogram at 72 hours of age • Significant nasal septal erosions (Superfical erosion or septal necrosis) daily until CPAP is weaned • Pneumothorax on lung ultrasound • Bronchopulmonary dysplasia – need for supplemental oxygen for =28 days • Length of hospital stay (days)	—

Measure

Time frame

• Total time on CPAP (days) • High grade (grades III and IV) intraventricular haemorrhage on cranial ultrasound before 7 days of age • Haemodynamically significant patent ductus arteriosus on echocardiogram at 72 hours of age • Significant nasal septal erosions (Superfical erosion or septal necrosis) daily until CPAP is weaned • Pneumothorax on lung ultrasound • Bronchopulmonary dysplasia – need for supplemental oxygen for =28 days • Length of hospital stay (days)

—

Countries

Uganda

Contacts

Public ContactMichael Egesa

Operations Officer

mpegesa_1@yahoo.com+256772633190

Outcome results

None listed