Circulatory System septic shock
Conditions
Interventions
dextrose
normal saline
Sponsors
faculty of medicine Alexandria university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? Septic shock defined as sepsis with persisting hypotension requiring vasopressors to maintain MAP = 65 mm Hg and having a serum lactate level >2 mmol/L (18 mg/dL) despite adequate volume resuscitation. ? Age = 18 years. ? Need for maintenance fluid as determined by the treating clinician ? Study intervention can be administered within 1 h of inclusion criteria being met.
Exclusion criteria
Exclusion criteria: ? Clinical situations that would render the primary endpoint difficult to interpret: • Chronic diuretic or decompression use. • Liver failure. • Treatment with parenteral feeding. • Confirmed or suspected pregnancy. • Patients in whom death is considered imminent (within 24 hours) ? Potential patient harm by the study fluids: • Severe heart failure. • Patients with intracranial pathology (eg; traumatic brain injury, Stroke). • Electrolyte disorders; ? A sodium level below 130 mmol/L or over 150 mmol/L or ? A potassium level below 3 mmol/L or over 5 mmol/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •The net cumulative fluid balance after 72 hours in ICU. | — |
Secondary
| Measure | Time frame |
|---|---|
| • All-cause mortality at 28 days post randomization.; • The relative change in haemodynamic variables, blood gas results Lactate, and electrolytes over the 72 h post randomization. ;ICU length of stay;duration of vasopressor requirement ;vasopressor free days;dose of vasopressor used;requirement for ventilation;duratin of ventilator support;ventilator free days;requirement for renal replacement therapy;duration of renal replacement therapy;renal replacement therapy free days;AKIN score to day 7;serum sodium;delirium incidence;delirium and coma free days | — |
Countries
Egypt
Contacts
Public ContactSamaa Abdelfatah
assisstant lecturer
Outcome results
None listed