Efficacy of Vonoprazan in Management of Post Endoscopic Variceal Ligation Ulcer

Efficacy of Potassium-Competitive Acid Blockers in Management of Post Endoscopic Variceal Ligation Ulcer

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

PACTR

Registry ID

PACTR202207793488326

Enrollment

300

Registered

2022-07-22

Start date

2022-07-21

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digestive System

Interventions

Vonoprazan

Pantoprazole

Placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients above the age of 18 years and below the age of 65 years who will be presented for elective band ligation of esophageal varices.

Exclusion criteria

Exclusion criteria: 1. Patients who had been subjected to injection sclerotherapy sessions. 2. Endoscopically confirmed pre-existing esophageal ulcers. 3. Barret's esophagus. 4. Previous surgical anti-reflux procedure. 5. Peptic ulcer disease diagnosed at the time of endoscopy. 6. Cardiofundal varices. 7. Pregnancy and lactation. 8. Diabetic patients and patients with advanced systemic disease as heart failure renal failure or any depleting disease that might affect healing process and\or life expectancy and as well those with suspected malignancy. 9. Allergy or past adverse reaction to investigated drugs. 10. Patients who will refuse to participate in the study.

Design outcomes

Primary

Measure	Time frame
1.Post endoscopic Variceal ligation ulcer: presence (Yes or No), number, and size [ Time Frame: At 2 weeks after intervention (EvL)] a.presence of post ligation ulcer (Yes/NO) b.the number of ulcers if present. c.the maximum dimension of an ulcer (if present) in millimeter. 2.Number of participants with Vonoprazan-related adverse events as assessed by TRAEs grouped by Medical Dictionary for Regulatory Activities version 19.1	—

Measure

Time frame

1.Post endoscopic Variceal ligation ulcer: presence (Yes or No), number, and size [ Time Frame: At 2 weeks after intervention (EvL)] a.presence of post ligation ulcer (Yes/NO) b.the number of ulcers if present. c.the maximum dimension of an ulcer (if present) in millimeter. 2.Number of participants with Vonoprazan-related adverse events as assessed by TRAEs grouped by Medical Dictionary for Regulatory Activities version 19.1

—

Secondary

Measure	Time frame
1. Symptoms related to EVL including: chest pain, dysphagia and vomiting 2. Patients compliance	—

Countries

Egypt

Contacts

Public ContactAbdelghany Aish

fellow at GOTHI

abdelghanyaish@gmail.com+201286775067

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026