Clinical trial to compare soacked combined tranexamic acid and epinephrine versus soaked epinephrine alone to reduce intraoperative bleeding in external dacryocystorhinostomy

Soacked combined tranexamic acid and epinephrine versus using soaked epinephrine to reduce intraoperative bleeding in external dacryocystorhinostomy, A double-blind, randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202206674510595

Enrollment

Registered

2022-06-28

Start date

2022-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases

Interventions

External dacryocystorhinostomy using gauze soaked epinephrine to control intraoperative bleeding

External DCR with combined tranexamic acid and epinephrine to control intraoperative bleeding

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with primary acquired nasolacrimal duct obstruction with or without +ve regurge test

Exclusion criteria

Exclusion criteria: 1- Hypertensive patients. 2- Patients with known allergy to tranxemic acid. 3- Patients with bleeding disorder, or on anti-coagulant therapy. 4- Patients with coexisting nasal pathologies which could influence the outcome of the surgery. 5- Patients with history of trauma or laceration to the lacrimal passages. 6- During the menstrual cycle in females

Design outcomes

Primary

Measure	Time frame
the amount of intraoperative bleeding (measured in millimeters) during external DCR using gauze soaked with combined tranexamic acid (100mg/ml) and epinephrine 1:200000 versus using gauze soaked only epinephrine 1:200000.	—

Secondary

Measure	Time frame
the mean surgical time of external DCR (measured in minutes) using gauze soaked with combined tranexamic acid (100mg/ml) and epinephrine 1:200000 versus using gauze soaked only epinephrine 1:200000.	—

Countries

Egypt

Contacts

Public ContactMarwa Ahmed Khairy

Assistant Lecturer of ophthalmology

ma_kh87@yahoo.com+201111801956

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026