A protocol to clinically evaluate liquid biopsies as a tool to speed up diagnosis of Children and Young adults with aggressive infection-related lymphoma in East Africa “(AI-REAL) “

Evaluation and Transfer of mobile whole slide tissue scanners and liquid biopsies to deliver fast and precise diagnosis for improved outcomes of children and young adults with EBV-driven lymphoma: a joint Tanzanian and Ugandan Paediatric Oncology Network Initiative

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202204822312651

Enrollment

146

Registered

2022-04-14

Start date

2019-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer

Interventions

Liquid biopsy samples will be collected from suspected EBV lymphoma cases and processed for ctDNA

The participants negative for EBV lymphoma by histopathology and liquid biopsy ctDNA test.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Children and young adults suspected of EBV lymphoma ages 3 years but before their 31st birthday.

Exclusion criteria

Exclusion criteria: Patients started on chemotherapy, and those unable, or unwilling, to provide written informed consent (and/or assent).

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the time from presentation to the specialist center to a final diagnosis of EBV lymphoma.	—

Secondary

Measure	Time frame
Secondary endpoints include the sensitivity and specificity of liquid biopsy and health economic benefits over histopathology.	—

Countries

Uganda, United Republic of Tanzania

Contacts

Public ContactErisa Sunday

Grants administrator African Field Epidemiology Network

serisa@afenet.net+256774569304

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026