COMPARISON BETWEEN THE EFFECTS OF LOW-LEVEL LASER THERAPY AND CRYOTHERAPY ON POST-ENDODONTIC PAIN

COMPARISON BETWEEN THE EFFECTS OF LOW-LEVEL LASER THERAPY AND CRYOTHERAPY ON POST-ENDODONTIC PAIN - A RANDOMISED CONTROLLED CLINICAL TRIAL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202204787113528

Enrollment

105

Registered

2022-04-14

Start date

2022-05-09

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health

Interventions

Low level laser

Cryotherapy

Root Canal Treatment without any adjunct

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Subjects who are willing to give informed consent and abide by the protocol of the research • Well-motivated subjects • Permanent teeth (except third molars) with matured apex • Carious permanent teeth (except third molars) with symptoms of irreversible pulpitis • Carious permanent teeth (except third molars) with acute apical periodontitis characterised by tenderness to percussion clinically. Radiographically, normal periodontal ligament space and lamina dura • Carious permanent teeth (except third molars) with acute apical periodontitis characterised by tenderness to percussion clinically. Radiographically, loss of lamina dura around the apex and periodontal ligament space widening • Carious permanent teeth (except third molars) with acute apical periodontitis characterised by tenderness to percussion clinically. Radiographically, small sized periapical radiolucency and loss of lamina dura. • Symptomatic carious permanent teeth (except third molars) requiring single-visit root canal treatment

Exclusion criteria

Exclusion criteria: • Subjects that are chronically ill and cannot tolerate a long dental procedure • Subjects with poorly controlled systemic conditions like poorly-controlled hypertension or diabetes • Pregnant females • Uncooperative patients • Patients with poor oral hygiene that cannot be improved within a limited time • Teeth with insufficient periodontal support • Teeth that cannot be restored to function • Subjects who have taken antibiotics within 3 days before treatment commences • Teeth requiring Root Canal Re-treatment • Teeth with weeping canals • Teeth with severely curved roots • Teeth with difficulty in determining the working length • Patients with complications during treatment such as broken files, over-instrumentation, overfilling, or incomplete filling • Permanent teeth with clinical and radiographical anomalies and anatomical variations

Design outcomes

Primary

Measure	Time frame
Post-operative pain reduction	—

Secondary

Measure	Time frame
Post-operative tenderness to percussion	—

Countries

Nigeria

Contacts

Public ContactOluwatosin Makanjuola

Senior Colleage

jomakanjuola@unilag.edu.ng+2348034096722

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026