Cancer Haematological Disorders Anaesthesia
Conditions
Interventions
Group T tranexamic acid group
group C placebo group
Sponsors
mansoura university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients scheduled for supratentorial brain tumor resection surgery. American Society of Anesthesiologists physical status (ASA) grades I, II and ???. Age between 20 and 60 years. either sex. Patients with Glasgow Coma Scale score (GCS) above 10
Exclusion criteria
Exclusion criteria: Patients who refused to participate in the study . Patients with infra tentorial tumors. Patients allergic to tranexamic acid. History suggestive of bleeding diathesis, thromboembolic episode prior to surgery or family history of thromboembolism, patients on medication that could interfere with coagulation. History of epilepsy. Associated sever uncompensated diseases(cardiac-respiratory-hepatic or renal diseases). Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| jugular venous oxygen saturation SjvO2 as the primary variant indicative for cerebral oxygenation and metabolism | — |
Secondary
| Measure | Time frame |
|---|---|
| perioperative assessment of blood loss, hemodynamics, the need of allogenic transfusion, any adverse effects of TXA, and surgical variables (length of surgery, anesthesia, PACU, intensive care unit (ICU) and hospitalization stay) | — |
Countries
Egypt
Contacts
Public ContactRania Elbadrawy
Rania E Elbadrawy
Outcome results
None listed