Mannitol for acute kidney injury during liver transplantation

Mannitol for prevention of Acute Kidney Injury during living donor Liver Transplantation: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202203622900599

Enrollment

Registered

2022-03-23

Start date

2017-11-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Disease

Interventions

Mannitol infusion on the start of warm ischemia

Saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult (= 18 years old) patients 2. Either sex 3. Undergoing living donor liver transplantation with right lobe graft from family-related donors.

Exclusion criteria

Exclusion criteria: 1. Acute fulminant hepatitis 2. Estimated Graft/Recipient Weight ratio (GRWR) 35 mmHg 4. Preoperative serum creatinine (SCr) > 1.4 mg/dl or dialysis within the last 3 months 5. Diabetes Mellitus (> 10 years) 6. Preoperative serum sodium [Na+] 5.5 mEq/L 7. Intra-operative massive blood transfusion (replacement of > 50% of total blood volume in < 3 hours)

Design outcomes

Primary

Measure	Time frame
Early acute kidney injury, defined as 0.3 mg/dl of SCr increase from the baseline in the early 48 post¬operative hours or 50% increase in the S. Cr within 48 hours.	—

Secondary

Measure	Time frame
All-cause mortality;Intensive Care length of stay;intraoperative CI, SVI, MAP, MPAP, CVP, PAOP, SVR, PVR, and serum [Na+], [K+], ionized [Ca2+], and [Cl-] at 6 intraoperative times - (1) immediately before skin incision, (2) the beginning of the an-hepatic (portal vein clamping), (3) 5 minutes before portal reperfusion (basal), (4) at 5 min after portal unclamping, (5) 5 minutes a;liver graft function	—

Measure

Time frame

All-cause mortality;Intensive Care length of stay;intraoperative CI, SVI, MAP, MPAP, CVP, PAOP, SVR, PVR, and serum [Na+], [K+], ionized [Ca2+], and [Cl-] at 6 intraoperative times - (1) immediately before skin incision, (2) the beginning of the an-hepatic (portal vein clamping), (3) 5 minutes before portal reperfusion (basal), (4) at 5 min after portal unclamping, (5) 5 minutes a;liver graft function

—

Countries

Egypt

Contacts

Public ContactMoataz Maher Emara

Clinical Lecturer of Anaesthesiology and Intensive Care at Mansoura University Faculty of Medicine

mm.emara@mans.edu.eg0201064048848

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026