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"Fresh start" text messaging to improve return to HIV care for adult patients who are lost to follow-up in the Capricorn District, South Africa.

"Fresh start" text messaging to improve return to HIV care for adult patients who are lost to follow-up in the Capricorn District, South Africa.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202202748760768
Enrollment
9630
Registered
2022-02-28
Start date
2022-04-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS

Interventions

Behavioural Insights Test Fresh start SMS messaging
Behavioural Insights Test Fresh start SMS messaging

Sponsors

University of Pennsylvania
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: • All adult patients aged 18 years and above who have previously initiated ART (either first-line or second-line ART) and have missed their last scheduled clinic appointments by more than 28 days. • The study will include patients who are routinely seen at the clinic as well as stable patients who have been enrolled into differentiated care models (decanting). For decanted patients, we will identify the patient’s missed clinic visit. • All patients included into the study must have a documented cell phone number on Tier.Net.

Exclusion criteria

Exclusion criteria: • All adult patients who have been documented as transferred out to another clinic. • All adult patients who are documented as deceased.

Design outcomes

Primary

MeasureTime frame
The proportion of patients re-initiating ART within 45 days of the first SMS text message being sent.

Secondary

MeasureTime frame
Not applicable - no secondary outcome is stated in the protocol. We will conduct a multivariable logistic regression with ART re-initiation as the binary outcome (dependent) variable and the following variables as the exploratory (independent) variables: i) study arm; ii) demographic variables- age, sex; iii) treatment characteristics- duration of treatment interruption, ART duration prior to treatment interruption; iv) level of direct service provision- intense vs limited; v) geographical location- sub-district; and vi) clinical variables- last viral load prior to treatment interruption, baseline CD4 count at ART initiation, new ART patient versus treatment experienced patient.

Countries

South Africa

Contacts

Public ContactChristine Njuguna

Public Health Analyst Anova Health Institute

njugunac@anovahealth.co.za+27722406866

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026