Soil-transmitted helminth, hookworm infection
Conditions
Interventions
single dose albendazole with avocado
Single dose albendazole without taking avocado
Dual dose albendazole without taking avocado
Dual dose albendazole with taking avocado
Sponsors
World Vision Uganda
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Children identified with hookworm infection in the January 2022 prevalence survey 2) Children attending randomly selected P4 and P5 classes in one of the randomly selected schools 3) Children whose parents/guardians provide written informed consent for the prevalence survey and for the nested trial if hookworm infection is detected.
Exclusion criteria
Exclusion criteria: 1) Children who received benzimidazole drugs such as albendazole and mebendazole within three months before the prevalence survey to avoid the residual effect of previously administrated drugs of albendazole. 2) Children who have a history of allergic reaction to albendazole or other benzimidazole drugs such as mebendazole.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cure rate The cure rate (CR) is defined as the percentage of infected individuals at prevalence survey that are free of infection three weeks after treatment. ;Egg reduction rate (ERR) Egg per gram (EPG): With the Kato-Katz method, the measure of EPG is obtained by multiplying the number of eggs counted on the slide. Considering the slide template holds 41.7mg of faeces, the multiplication factor to obtain EPG is 24. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events from the clinical trial | — |
Countries
Uganda
Contacts
Public ContactBomax Otim
Project coordinator
Outcome results
None listed