Effect of Amikacin-Embeded Humidifier on prevention of circuit colonisation and incidence of early ventilator associated pneumonia in critically ill patients

EFFECT OF AMIKACIN-EMBEDDED HUMIDIFIER ON CIRCUIT COLONIZATION AND INCIDENCE OF EARLY VENTILATOR-ASSOCIATED PNEUMONIA IN MECHANICALLY VENTILATED PATIENTS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202202537632410

Enrollment

Registered

2022-02-15

Start date

2022-03-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory

Interventions

Amikacin

Sterile Water for injection

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All adult patients admitted to ICU for mechanical ventilation Patients requiring admission for greater than 48hours

Exclusion criteria

Exclusion criteria: ? Patients with age less than 18years old. ? Prior diagnosis of Sepsis in the patient ? Patients already on Amikacin ? Ongoing chest infection in the patient ? Diabetes mellitus ? Malignancies ? Chronic kidney disease ? Chronic liver disease ? Refusal to give consent

Design outcomes

Primary

Measure	Time frame
To determine the effect of amikacin-embedded heated water bath humidifier in the prevention of ventilator circuit colonization and ventilator-associated pneumonia in mechanically ventilated patients in the intensive care unit	—

Secondary

Measure	Time frame
1. To determine the incidence of ventilator circuit colonization in mechanical ventilated patients, within 96 hours of ICU admission. 2. To determine and compare the incidence of ventilator associated pneumonia in patients using and those not using amikacin- embedded humidifiers. 3. To determine the relationship between ventilator circuit colonization and the development of ventilator-associated pneumonia in the two groups 4. To determine the pattern of bacteria colonization in the ventilator circuit in the two groups in the first 96 hours of ICU admission. 5. To compare the ventilator circuit bacteria colonies to those cultured in the tracheal aspirate in the two groups.	—

Measure

Time frame

1. To determine the incidence of ventilator circuit colonization in mechanical ventilated patients, within 96 hours of ICU admission. 2. To determine and compare the incidence of ventilator associated pneumonia in patients using and those not using amikacin- embedded humidifiers. 3. To determine the relationship between ventilator circuit colonization and the development of ventilator-associated pneumonia in the two groups 4. To determine the pattern of bacteria colonization in the ventilator circuit in the two groups in the first 96 hours of ICU admission. 5. To compare the ventilator circuit bacteria colonies to those cultured in the tracheal aspirate in the two groups.

—

Countries

Nigeria

Contacts

Public ContactAbiodun Olabisi Ojedoyin

Senior Registrar

abeyhoney@gmail.com+2348060186314

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026