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Effectiveness of Chlorhexidine vaginal cleansing in reducing postcaesarean surgical site infection and endometritis at two tertiary hospitals in Enugu, Nigeria: a randomized controlled trial

Effectiveness of Chlorhexidine vaginal cleansing in reducing postcaesarean surgical site infection and endometritis at two tertiary hospitals in Enugu, Nigeria: a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
PACTR
Registry ID
PACTR202201669178899
Enrollment
510
Registered
2022-01-05
Start date
2018-09-03
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth Surgery Post caesarean endometritis and wound infection

Interventions

No vaginal cleansing

Sponsors

Coal City Dissertation Research Grant Award by Profs Echezona E Ezeanolue and Chima A. Onoka in Collaboration with College of Medicine University of Nigeria Nsukka
Collaborator

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: All pregnant women who had been billed for caesarean delivery either electively or as emergency and given consent at the two Obstetrics units (ANW and Labour wards) of the two study centers were included

Exclusion criteria

Exclusion criteria: women with clinical diagnosis of chorioamnionitis women with diagnosis of obstructed labour women with contraindications to caesarean delivery women with contraindication to chlorhexidine use such as history of serious allergic reaction women with premature rupture of membranes, HIV/AIDs, diabetes mellitus and hemoglobin <10g/dl that could not be corrected before surgery

Design outcomes

Primary

MeasureTime frame
Proportion of women who received vaginal cleansing with chlorhexidine and had endometritis or surgical site infection or both

Secondary

MeasureTime frame
proportion of babies admitted into the Newborn Special Care within 72 hours of birth for APGAR Score 7, neonatal sepsis, neonatal jaundice and other causes.

Countries

Nigeria

Contacts

Public ContactJohnpaul Nnagbo

Department of Obstetrics and Gynaecology University of Nigeria Teaching Hospital Ituku Ozalla Enugu State

nnagbo1@gmail.com+2348066731322

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026