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Efficacy and safety of four-weeks versus twelve-weeks loading doses spacing of intravitreal Aflibercept for treatment of macular edema associated with Central Retinal Vein Occlusion

Efficacy and safety of four-weeks versus twelve-weeks loading doses spacing of intravitreal Aflibercept for treatment of macular edema associated with Central Retinal Vein Occlusion

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202201655513401
Enrollment
60
Registered
2022-01-17
Start date
2022-03-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases

Interventions

intravitreal injection of aflibercipt

Sponsors

Egypt health insurance
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Any participant to be included in the study should have: normal or controlled blood pressure. normal Hba1c or controlled (maximum 6.5%). normal or controlled lipogram. Patients aged =18 years with center-involved macular edema due to CRVO (CMT =250 µm on OCT). Best corrected visual acuity (BCVA) of 20/40 to 20/320 (73 to 24 letters)

Exclusion criteria

Exclusion criteria: Exclusion criteria comprised the following: pregnancy or lactation. glaucoma. cataract. previous vitreoretinal or filtration surgery. iris neovascularization. any systemic or ocular disorder in the study eye that may confound the interpretation of the study results. previous treatment with any anti-VEGF agents. systemic anti-angiogenic medications. intraocular corticosteroids

Design outcomes

Primary

MeasureTime frame
Best corrected visual acuity changes at follow up time points.

Secondary

MeasureTime frame
Changes in central macular thickness and choroidal thickness as measured by OCT. Reporting any ocular or systemic complications related to intravitreal injection of Aflibercept.

Countries

Egypt

Contacts

Public ContactGamal El Deen Rashed

Dr. Gamal El Deen Rashed. staff member ophthalmology department Asyut university

gamaleldeen.rabea@med.au.edu.eg+201061822306

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026