Effect of Dexmedetomidine vs Midazolam on the microcirculation of septic patients who are mechanically ventilated

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202112845314910

Enrollment

128

Registered

2021-12-01

Start date

2020-02-16

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System sepsis Anaesthesia

Interventions

dexmedetomidine infusion

midazolam infusion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Both males and females • Age more than 21 years old • Patients having sepsis requiring sedation for mechanical ventilation, according to the third international consensus definitions for sepsis and septic shock (sepsis-3).

Exclusion criteria

Exclusion criteria: Pregnant or breast-feeding women • Age < 21 years old • Allergy to any of the drugs used in the study • 2nd or 3rd degree Heart block • Systolic blood pressure < 90 • Patient with EF < 30% example (Heart failure, MI) • HR < 50 bpm • Child B or C cirrhotic liver disease • Documented Acute coronary syndromes • Presence of Intra-cardiac shunts • The need to use positive inotropic drugs for circulatory support

Design outcomes

Primary

Measure	Time frame
The effect of Dexmedetomidine on the microcirculation in sepsis, by direct assessment through perfusion index.	—

Secondary

Measure	Time frame
Indirect assessment of the microcirculation in both groups will be done through global markers of perfusion as P(v-a)Co2, ScVO2, and Mean Arterial Pressure (MAP).	—

Countries

Egypt

Contacts

Public ContactOsama Mansour

Vice Dean of research committee at faculty of medicine

viced.research@med.asu.edu.eg+20224346344

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026