Anaesthesia
Conditions
Interventions
the cryoprecipitate group
the placebo group
Sponsors
Rabab Saber Mahrous
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ASA grade I-III, adolescents who were to undergo major elective scoliosis surgery expected to last at least 4 hours
Exclusion criteria
Exclusion criteria: bleeding disorder, pre-existing thrombocytopenia and/or anemia, prior thromboembolic disease, hemorrhagic diathesis, established hypersensitivity to fibrinogen concentrate, active infectious disease, overweight (BMI>35), left ventricular ejection fraction below 45%, significant cardiac arrhythmias, valvular lesions, perioperative renal insufficiency, impaired hepatic function, allergy to any drug used in this study, preoperative infection and intake of acetylsalicylate within 2 weeks or nonsteroidal anti-inflammatory drugs within 7 days before surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint was the volume of peri-operative transfused blood products (pRBCs, FFP and concentrated platelets) during the whole stay in hospital. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary endpoint was the volume of peri-operative blood loss, defined as the sum of the blood loss measurements during surgery, and the precisely measured volume of postoperative blood loss during the stay on the ICU. | — |
Countries
Egypt
Contacts
Public ContactRabab Mahrous
Assistant prof of Anesthesia Alexandria University
Outcome results
None listed