A randomized controlled clinical trial using alpha-tocopherol and ascorbic acid in the treatment of moderate traumatic brain injury

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202112742845790

Enrollment

120

Registered

2021-12-24

Start date

2017-10-10

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery

Interventions

alpha tocopherol group

ascorbic acid group

Combination group

Control group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 16yrs and above 2. Moderate head injury (GCS: 9-12) 3. Acute phase of trauma at 72hours or less 4. Brain CT scan within 72hours of injury

Exclusion criteria

Exclusion criteria: 1. Patients with space-occupying lesions requiring emergency evacuation 2. Patients with TBI duration greater than 72hrs 3. Patients with a previous history of craniotomy or any significant neurosurgical intervention 4. Patients with significant concomitant extracranial injuries 5. Patients with history of liver disease, renal disease or bleeding diathesis

Design outcomes

Primary

Measure	Time frame
Glasgow outcome score, mortality and lenght of hospital stay	—

Secondary

Measure	Time frame
Demographics of head injury in adults presenting to Jos University Teaching Hospital	—

Countries

Nigeria

Contacts

Public ContactKyesmen Nanpan

Neurosurgical Specialist Registrar

nipan007@gmail.com+2348032107513

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026