Impact of pressure targeted modes of ventilation on diaphragmatic function as assessed using ultrasonography in critically ill patients with cerebral insult

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202112653971335

Enrollment

Registered

2021-12-07

Start date

2020-02-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Anaesthesia

Interventions

Diaphragmatic function as asssessed using ultrasonography in Pressure support ventilation mode.

Diaphragmatic function as assessed using ultrasonography in Assist Control Pressure controlled mode.

Diaphragmatic function as asssessed using ultrasound in Synchronized Intermittent Mandatory mode

Diaphragmatic function as assessed using ultrasound in Bilevel Positive Airway Pressure mode

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Patients age = 21 years. • Both genders. • Mechanically ventilated patients due to primary cerebral insult (ischemic or hemorrhagic or embolic incident) or secondary to traumatic brain injury in ER or OR. • Eligible for proposed pressure targeted modes of mechanical ventilation. • Afebrile. • Hemodynamically stable patients or with minimal doses of vasopressors or inotropes. • Minimal doses of sedation if needed.

Exclusion criteria

Exclusion criteria: • Refusal of the legal guardians to the intervention or participation of the patient in the study. • Use of Neuromuscular blockers. • Patient < 21 years old. • Diaphragmatic dysfunction on ICU admission. • History of Diaphragmatic palsy or Diaphragmatic hernia. • History of brainstem injury or cervical spine injury or neuromuscular disease. • Severe Hemodynamically unstable patients. • Presence of ascites or colonic distention or any mechanical factor in the chest or abdomen interfering with diaphragmatic mobility. • Presence of chest deformities or pneumothorax or pneumomediastinum or pleurodesis or moderate to severe pleural effusion or surgical emphysema in the chest. • Rhabdomyolsis. • Cachectic and malnourished patients. • Pregnancy. • Psychiatric illness. • Patients with chronic pulmonary disease or respiratory failure.

Design outcomes

Primary

Measure	Time frame
1.Diaphragmatic motion in terms of Diaphragmatic Excursion (DE) during spontaneous breathing trails. 2.Diaphragmatic thickness in terms of Diaphragmatic Thickness Fraction (DTF).	—

Secondary

Measure	Time frame
1. Total duration of ventilation. 2. Length of ICU stay.	—

Countries

Egypt

Contacts

Public ContactMohamed Mohamed Kamal

lecturer

Dr_Medo2000@hotmail.com+201003787898

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026