Musculoskeletal Diseases Nervous System Diseases Surgery Anaesthesia
Conditions
Interventions
Sevoflurane
Propofol
Sponsors
Department of Anesthesia and surgical ICU Faculty of medicine Alexandria University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with American Society of Anesthesiologists score of I–II, of both sex, age 65 years or older, have a sufficient level of education to be capable of completing neuropsychological tests, do not have serious hearing or vision impairment and are able to read.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Patient’s refusal. 2. ASA III/IV. 3. Mini Mental State Examination (MMSE) score less than 26. 4. Patients with severe hepatic, renal or cardiovascular disease. 5. Pre-existing neurological, dementia or neuropsychological disease 6. Current use of sedatives, antidepressants or corticosteroids 7. History of cerebral surgery or recent stroke. 8. History of alcohol abuse or drug addict. 9. Intraoperative events requiring interventions not included in the study protocol such as excessive blood loss and severe hypotension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is: Incidence of cognitive dysfunction 120 minutes and 24 hours postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome is: • The changes of serum level of S100 beta as a measure of neuronal damage and to correlate the association between S100 beta serum level and incidence of postoperative cognitive dysfunction. • Haemodynamic status. • Use of vasoactive drugs | — |
Countries
Egypt
Contacts
Public ContactRania Abo Elfetouh
Lecturer of Anesthesia and Surgical ICU Alexandria University
Outcome results
None listed