Vitamin D status in undernourished children

Vitamin D status in relation to systemic and intestinal inflammation in undernourished children, 6-59 months old

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202110646172601

Enrollment

175

Registered

2021-10-22

Start date

2021-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional, Metabolic, Endocrine

Interventions

Vitamin D

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Undernutrition group: MUAC 12.5 cm or WHZ > -1 SD but = 2SD, Height-for-age > -1 SD

Exclusion criteria

Exclusion criteria: Fever (ear temperature > 38 ?C) Persistent cough in the past 2 weeks Blood transfusion in the past month Medical record diagnosis of malabsorption syndrome Persistent diarrhoea or vomiting in the past 3 days Chronic medications including anticonvulsants (phenobarbital, carbamazepine, phenytoin), antibiotics (rifampicin, isoniazid), antiretroviral medications (protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs); e.g. efavienz, darunavir and ritonavir Medical record diagnosis of conditions associated with vitamin D hypersensitivity (i.e. sarcoidiosis, primary hyperparathyroidism Children already receiving treatment for vitamin D deficiency Haemoglobin < 70 g/L

Design outcomes

Primary

Measure	Time frame
The association of vitamin D status with plasma IL6 and IL8 and intestinal fatty acid-binding protein in undernourished compared to apparently healthy non-malnourished children	—

Secondary

Measure	Time frame
The relationship of vitamin D status with systemic (CRP and AGP) and intestinal inflammation (plasma intestinal fatty acid-binding protein) before and after three doses of 50,000 IU of vitamin D. ;The relationship between vitamin D status and iron status markers (Hb, sTfR and ferritin) and status (ID, IDE, anaemia and IDA) before and after three doses of 50,000 IU of vitamin D;To assess the association between vitamin D status and anthropometry (MUAC, weight, height/length, weight-for-height, weight-for-age, height-for-age z-scores) ;To assess the association of systemic and intestinal inflammation with anthropometry (MUAC, weight, length/height, WAZ, WHZ and HAZ);To assess the determinants of vitamin D status in undernourished and healthy children 6-59 months old, in the JB Marks municipality, North-West Province	—

Measure

Time frame

The relationship of vitamin D status with systemic (CRP and AGP) and intestinal inflammation (plasma intestinal fatty acid-binding protein) before and after three doses of 50,000 IU of vitamin D. ;The relationship between vitamin D status and iron status markers (Hb, sTfR and ferritin) and status (ID, IDE, anaemia and IDA) before and after three doses of 50,000 IU of vitamin D;To assess the association between vitamin D status and anthropometry (MUAC, weight, height/length, weight-for-height, weight-for-age, height-for-age z-scores) ;To assess the association of systemic and intestinal inflammation with anthropometry (MUAC, weight, length/height, WAZ, WHZ and HAZ);To assess the determinants of vitamin D status in undernourished and healthy children 6-59 months old, in the JB Marks municipality, North-West Province

—

Countries

South Africa

Contacts

Public ContactMartani Lombard

Senior lecturer North West University

tani.lombard@nwu.ac.za+27832854770

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026