Nervous System Diseases
Conditions
Interventions
IV alteplase
loading antiplatelets
Sponsors
neurology department ain shams university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults (~18 years or over) undergoing elective or emergency PCI. 2. Acute ischemic stroke, defined as focal neurological deficit occurring during or immediately after PCI, and diagnosed by an expert neurologist. 3. Stroke within 4 hours of onset. 4. National institutes of health stroke scale (NIHSS) ranging from 4-15. 5. NIHSS < 4 if causing significant deficit (e.g.: aphasia). 6. CT brain is negative for hemorrhage. 7. Patients fulfilled the inclusion criteria for TPA. 8. All participants or their relatives give written consent for participation in this study.
Exclusion criteria
Exclusion criteria: 1- Adolescents or children (15). 4- Mild neurological deficit (NIH <3) and no strategic deficit. 5- Stroke onset beyond 4.5 hours 6- Exclusion criteria for TPA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in NIHSS score from baseline to 24hrs and on discharge . ; Rate of significant bleeding events and the rate of mortality during the hospital stay ; Change in NIHSS score from baseline to 24hrs and on discharge . ; Rate of significant bleeding events and the rate of mortality during the hospital stay | — |
Secondary
| Measure | Time frame |
|---|---|
| secondary outcome measures were mRS on discharge and after 3months ;duration of hospital stay | — |
Countries
Egypt
Contacts
Public Contactahmed elbasiouny
professor
Outcome results
None listed