Musculoskeletal Diseases
Conditions
Interventions
Combined PRP and botulinum toxin injection
PRP injection
Sponsors
Mansoura university hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Age of 40–70 years old Suffering from knee pain in the past six months History of complaints for at least one month The need for painkillers Knee osteoarthritis was confirmed by radiography (Kellgren-Lawrence classification grade 2–3).
Exclusion criteria
Exclusion criteria: presence of systemic disorders (ie, diabetes mellitus, immunodeficiency, and collagen vascular diseases) the history of malignancy, the history of autoimmune diseases or platelet disorders, body mass index of over 33 kg/m2, the presence of IAIs within the past three months before the injection, the history of a recently occurred severe knee trauma, knee septic arthritis, the active ulcer or septic arthritis of the knee, genu varum or valgum of over 20°, history of clinically significant cardiac, hepatic, renal, or neurological dysfunction, coagulopathy, known allergy to study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The reduction of pain and an improvement of function after intraarticular injections | — |
Secondary
| Measure | Time frame |
|---|---|
| patients’ satisfaction | — |
Countries
Egypt
Contacts
Public ContactIbrahim Abdelbasir
Assistant professor of anesthesia and surgical Intensive care at faculty of medicine Mansoura university
Outcome results
None listed