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“Weaning modes” of mechanical ventilation in patients with “difficult weaning”

A comparative study among three “weaning modes” of mechanical ventilation in patients with “difficult weaning”

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
PACTR
Registry ID
PACTR202108881017604
Enrollment
105
Registered
2021-08-25
Start date
2021-06-15
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Anaesthesia

Interventions

Sponsors

Faculty of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: difficult weaning” of mechanical ventilation (defined as failure of first Spontaneous Breathing Trial (SBT) or reintubation within 48 hours after the first extubation attempt in patients who fulfill readiness criteria for weaning)

Exclusion criteria

Exclusion criteria: - Age less than 18 or more than 75 years old - Body mass index more than 35 kilogram/ meter 2 - Respiratory arrest or apnea - Chest trauma - Acute respiratory distress syndrome - Brain stem infarction, hemorrhage or death - Cervical spinal cord injury - High risk of aspiration e.g.; cerebral stroke with bulbar manifestations - Acute or chronic myopathy or polyneuropathy affecting respiratory muscles - Cardiomyopathy (Ejection fraction less than 45%) - Severe shock state on high doses of vasopressors - Post Major operations - Burst abdomen - Lack of informed consent

Design outcomes

Primary

MeasureTime frame
rate of successful weaning of mechanical ventilation

Secondary

MeasureTime frame
total ‘weaning’ time (TWT).;total duration of mechanical ventilation (TMVT)

Countries

Egypt

Contacts

Public ContactYaser Fathy

Assistant professor

criticalcare65@gmail.com00201099004664

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026