The interaction of Antiretroviral Drugs with the Microbiome

The interaction of Antiretroviral Drugs with the Microbiome: Implications on the development of cardiovascular diseases in HIV+ persons

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202108587192356

Enrollment

300

Registered

2021-08-25

Start date

2020-08-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System HIV/AIDS Nutritional, Metabolic, Endocrine

Interventions

No intervention

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 60>Age ?18 years at the time of signing a consent form 2. Signed consent form 3. Resident of Mthatha and surrounding rural areas for the past 12 months 4. Have received counseling pre – and post-testing for HIV 5. Reports overnight fast

Exclusion criteria

Exclusion criteria: 1. Use of antibiotics 2. Antidiabetic medication 3. Gastrointestinal disease 4. Smoking 5. Tested COVID19 positive in the three months prior to the data collection

Design outcomes

Primary

Measure	Time frame
Quantify and characterise HIV related gut microbial shift and vascular function and how this is modulated by ART.	—

Secondary

Measure	Time frame
2. Improved HIV/AIDS & COVID19 awareness in the study community	—

Countries

South Africa

Contacts

Public ContactOdwa Shibe

Secretary

oshibe@wsu.ac.za0026475022352

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026